Direct access to functionalized azepanes by cross-coupling with α-halo eneformamides

Abstract

The synthesis of functionalized azepanes was accomplished through the palladium-mediated cross-coupling of α-halo eneformamides with mostly unactivated nucleophiles under mild conditions. Alkenylations proceeded with excellent stereoselectivitiy. In most cases, high yields of the coupling products were obtained. © 2014 American Chemical Society.