Nano metal-complexes of theophylline derivative: Synthesis, characterization, molecular structure studies, and antibacterial activity

Abstract

The new divalent nano metal-complexes of Zn(II), Mn(II), and Fe(II) with new ligand derivate from theophylline were synthesis by ultrasonic sonication method. This method was applied to produce smaller, narrow distributed nanoparticles and without any aggregations. The nanocomplexes and new ligand (L) were diagnosed by different Physico-chemical studies as Analysis of elements (C.H.N), Measuring conductivity, FT-IR spectra, 1H NMR spectra, UV-Vis spectra, flame atomic absorption (FAA), and their microbial activities. The spectroscopic data of the nanocomplexes suggest their 2:1 (L: M) complex structures of Mn(II), Fe(II), and 1:1 (L: M) complex structure of Zn(II). Also, the spectroscopic studies suggested the octahedral structure for Mn(II) and Fe(II) ions and tetrahedral structure for Zn(II) ion. All spectroscopic data propose that new ligand act as a bidentate ligand with its metal ions. The size and morphology of nanocomplexes measured by TEM were in range (14-18) nm. The bacterial activity was checked with the synthesized ligand and nanocomplexes. Activities show that the nano complexes are more promising than their new ligand for microbial activities.