Palmitoylation-dependent membrane localization of the rice resistance protein pit is critical for the activation of the small GTPase OsRac1

Abstract

Background: Mechanisms and significance of immune receptor R protein localization to specific compartments remain unknown. Results: Palmitoylation-deficient R protein Pit fails to induce GTPase OsRac1 activation at the plasma membrane, thereby compromising Pit-mediated disease resistance. Conclusion: Palmitoylation-dependent membrane localization of Pit contributes to Pit-mediated disease resistance through OsRac1 activation. Significance: Elucidating relationships between R protein localization and activation of downstream molecules improve our understanding of plant immunity. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.