Antimicrobial Effect of Titanium Oxide (Tio2) Nano Particles in Completely Edentulous Patients. A Randomized Clinical Trial

Abstract

Objective: to investigate the effect of addition different concentration of TiO2 nanoparticles on acrylic resin polymethyl methacrylate to improve the anti-microbial properties of denture base material Subjects and Methods: 24 completely edentulous patients were selected to be enrolled in of the following groups: Group I: 8 patients were rehabilitated with complete dentures had no nanoparticle (Control group),Group II: 8 patients were rehabilitated with complete dentures had a 1% concentration of titanium oxide nanoparticles and Group III: 8 patients were rehabilitated with complete dentures had a 3% concentration of titanium oxide nanoparticles. Microbiological evaluation was done from the fitting surface of dentures after one week, two weeks, and one month of denture use. Results: Regarding staphylococcus aureus and candida albicans colonization, the result revealed that between one week, two weeks, and one month follow up periods for each group and between different groups for each follow up period, there was a statistically significant difference between all groups. Regarding staphylococcus epidermis colonization, there was negative colonization of staphylococcus epidermis. Conclusion: Addition of TiO2 nano particles with 1% and 3% concentrations to PMMA has a great anti-microbial effect with reduction of the colonization of S. aureus, S. epidermis and C. albicans than the conventional dentures.