Identification of a putative second T-cell receptor

Abstract

Framework monoclonal antibodies have identified a population of human lymphocytes that express the T3 glycoprotein but not the T-cell receptor (TCR) α- and β-subunits. Chemical crosslinking experiments reveal that these lymphocytes express novel T3-associated polypeptides, one of which appears to be the product of the Tγ gene. The other polypeptide may represent a fourth TCR subunit, designated Tδ. © 1986 Nature Publishing Group.