Current Strategy to Target Bacterial Quorum Sensing and Virulence by Phytocompounds

Abstract

The emergence of multidrug-resistant pathogens and the slow development of new potent drugs has become a public health concern across the globe. Plants as novel drug candidates are very appropriate, as they produce wide array of secondary metabolites with diverse biological activities. The traditional methods to tackle drug resistance are slowly becoming ineffective, therefore, targeting microbial quorum sensing (QS) rather than survival seems to be a good alternative strategy, as interference with QS and its regulated virulence factor is less susceptible to development of resistance. This review presents a database of the phytocompounds with QS inhibitory activity against Gram-positive and Gram-negative bacterial pathogens.