Possible Therapeutic Role of Cholinergic Agonists on COVID-19 related inflammatory response

Abstract

Severe acute respiratory syndrome-corona virus-2 (SARS-CoV-2) or coronavirus infectious disease (COVID-19) outbreak is continued to spread all over the world recently with the high mortality and morbidity rates. It is also known well coronavirus infectious disease is leading causes of acute lung injury and acute respiratory distress syndrome (ARDS), septic shock and multi organ failure. Current treatment of COVID-19 includes different strategies targeting preventing viral replication or treating secondary infections and decreasing exaggerated immune response. Although antiviral, antimicrobial, immunomodulatory agents including anti-cytokines and glucocorticoids have been currently applied; there is lack of a specific treatment for COVID-19. In this review, possible therapeutic roles of cholinomimetic drugs in the control of COVID-19 are discussed.