Effect of carbonated drinks on the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and kidney in Rattus novergicus

Abstract

The effect of carbonated drink also known as pop soda was studied in this research. The aim of this study was to check the possible effect on the activities of the kidney biomarkers [alanine aminotransferase (ALT) and aspartate aminotransferase (AST)] in Rattus novergicus. The results from this study revealed that the activities level of serum ALT of group A (24.1±5.8) showed a significant increase at (p<0.05) when compared with that of the control C (10.0±2.72) while that of group B (1.75±1.66) showed a significant decrease in enzyme activity when compared with that of the control. It was also revealed that there was significant increase in AST enzyme activity in brand B (24.2±6.38) when compared with that of the control C (17.0±1.94) at (p<0.05). The result from the investigation of kidney ALT and AST activities showed that there was a slight increase in AST activity with brand B (17.70±1.68) when compared with that of the control (16.70±2.52) at (p>0.05), While the kidney ALT level for brand A and B were reduced when compared with that of the control (p>0.05). The results of the study suggest that over consumption of carbonated drink may cause liver injury thereby increasing the liver enzyme activity, however overconsumption of carbonated drinks may cause problem to the kidney if there is alteration of kidney architecture. The results from the research showed that for healthy kidney, overconsumption of carbonated drinks may have no effect. © 2012 Academic Journals Inc.