Pancreatic adenocarcinoma treatment hellenic oncology survey 'PATHOS': Frequency and current treatment modalities of advanced pancreatic adenocarcinoma in greece

ISSN: 1792345X
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Abstract

Background: Advanced pancreatic adenocarcinoma (APA) remains a difficult to manage disease with a high mortality rate. Limited data is available from the Greek Cancer Registry on patients with pancreatic cancer. Patients & Methods: The PATHOS multicenter survey aimed at capturing real-world data on pancreatic cancer disease status in Greece. A standardized questionnaire administered to ten interviewed physicians specialized in pancreatic cancer, captured data from patient medical records as well as the physicians' opinion about limitations of the most common treatment modalities for APA and the likelihood of using nab-paclitaxel in the metastatic APA population. Results: During 2011, 187 patients with APA, 63.6% of whom had been diagnosed with metastatic (Stage IV) disease, were treated by the participating physicians. Surgery had been performed in 39.7% of patients with locally advanced and in 8.4% of those with metastatic APA. Overall, 62/68 patients with locally advanced disease received chemotherapy (31 adjuvant/neoadjuvant). Of 119 patients with metastatic disease, 101 received chemotherapy (7 adjuvant; 94 palliative). As part of standard practice, 89% of patients with metastatic APA had received firstline therapy, mainly with gemcitabine, gemcitabine +erlotinib or FOLFIRINOX. However, various limitations were reported for gemcitabine +erlotinib and FOLIFIRINOX, underscoring the need for new treatments. Of the physicians, 80% reported that they were highly likely to use the combination of nab-paclitaxel/gemcitabine for metastatic APA in the future. Conclusions: The survey demonstrated that APA in Greece is mostly diagnosed in the metastatic state and underscored the importance of adding new treatment modalities to the current therapeutic armamentarium.

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Souglakos, J., Karavasilis, V., Tsotra, E., Samantas, E., Sgouros, I., Basta, E., … Stathopoulou, E. (2013). Pancreatic adenocarcinoma treatment hellenic oncology survey “PATHOS”: Frequency and current treatment modalities of advanced pancreatic adenocarcinoma in greece. Forum of Clinical Oncology, 4(4), 11–19.

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