Synthesis and configuration determination of enantiomerically pure 4,10-di-substituted tröger's base derivatives

Abstract

A practical and scalable method for synthesis and resolution of 4,10-di-substituted Tr̈ger's base derivatives is described. By combination of circular dichroism (CD) spectra and X-ray diffraction (XRD) analysis method, the absolute configuration on two sterogenic nitrogen atoms of the crucial intermediate (-)-diastereomer is assigned as 5S,11S.