Validation of microRNA expression profile in oral lichenoid disease through cytological samples

2Citations
Citations of this article
10Readers
Mendeley users who have this article in their library.

Abstract

Background: To validate oral exfoliative cytology in the analysis of the microRNA expression profile in Oral Lichenoid Disease (OLD). Material and methods: The expression of 13 microRNAs identified and presented by our group in a previous study was analyzed in 26 cases, 16 diagnosed as OLD and 10 controls with no oral mucosal pathology. Cytological samples from the oral mucosa obtained using an Orcellex toothbrush were analyzed using RT-qPCR and TaqMan microRNA assays. Results: The aberrant expression was validated for 2 microRNAs (miR-146a-5p and miR-7-1-3p) of those previously recognized in the biopsy study. Conclusions: This is the first time that oral exfoliative cytology is validated in a study of the alterations of the expression of microRNAs in OLD. The alteration of miR-146a and miR-7 compared to controls was validated. These microRNAs are associated with both inflammatory and carcinogenic phenomena that are involved in the etiopathogenesis of this potentially malignant oral disorder.

Cite

CITATION STYLE

APA

Setién-Olarra, A., Marichalar-Mendia, X., Fernández-Pacheco, J. A., Fernán-Dez-barriales-lópez, M., Gainza-Cirauqui, M. L., & Aguirre-Urizar, J. M. (2019). Validation of microRNA expression profile in oral lichenoid disease through cytological samples. Medicina Oral Patologia Oral y Cirugia Bucal, 24(5), e610–e614. https://doi.org/10.4317/medoral.23020

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free