Resistance to azole compounds in ENt and genital infections produced by Candida species

Abstract

Candida albicans species is located in the oral cavity, digestive tract and genital region as the commensal flora in more than half of the healthy population. Infection with species of Candida genus is the most common cause of vaginal infections, second only to bacterial vaginitis. Candida albicans species is ubuquitous commensal yeast that develops in the mucous membranes. Under normal conditions of host health, this microorganism is in balance with the microbiota of these areas but also with the host’s immune system. The aim of this study was to determine and compare the sensibility and the resistance of some Candida albicans strains isolated from oro-pharyngeal and vaginal secretions to different azole compunds. In the case of oro-pharyngeal infections, most of the Candida isolated species were resistant to ketoconazole, itraconazole and fluconazole and in the case of isolated species in vaginal infections the resistance was increased in the case of fluconazole, itraconazole and ketoconazole, in different percentages compared to oro-pharyngeal site.