A role for the circadian clock protein per1 in the regulation of the NaCl Co-transporter (NCC) and the with-no-lysine Kinase (WNK) cascade in mouse distal convoluted tubule cells

Abstract

Background: The role of the circadian protein Per1 in the regulation of sodium reabsorption in the distal convoluted tubule (DCT) is unknown. Results: Per1 transcriptionally regulates the sodium transporter NCC and the WNK kinase cascade. Conclusion: Per1 regulates sodium reabsorption in the DCT through NCC and the WNK cascade. Significance: These data demonstrate a role for Per1 in the regulation of renal sodium transporters.