Recent advances of transition metal-catalyzed C(sp3)-C(sp3) cross-coupling reactions of non-activated alkyl halides

Abstract

Recently, great attention has been directed to the transition-metal-catalyzed cross-coupling reactions of non-acti-vated alkyl halides for the construction of C(sp3)-C(sp3) bonds. However, due to the difficulty of oxidative addition of the non-activated alkyl halides with a metal catalyst and the resulting metal-alkyl intermediate prone to β-H elimination, the cross-coupling of non-activated alkyl halides with alkyl nucleophiles remains a challenge. This review summarizes the recent advances of C(sp3)-C(sp3) cross-coupling of non-activated alkyl halides catalyzed by transition-metals.