The utilization of black rice yeast and its physiological effects on mice (Mus musculus) which are exposed to type 2 diabetes mellitus

Abstract

Black rice is widely available in nature and rich in nutrients. The research aimed at utilizing yeast-black rice (yeast-BR) and its physiological effects on mice exposed to type 2 diabetes mellitus (type 2 DM). Mice were induced by high fat and fructose diet then classified and treated as follows: 1) DM + yeast-BR; 2) DM + glibenclamide; 3) DM; and 4) Non-DM. All groups were given commercial feed. The treatment was given for 10 days and then tested for the physiological effects (decreasing blood glucose levels, the volume of drinking water and urine, diet, and absorption of chromium by the small intestine). The results show 1) the highest reduction in blood glucose levels was treated with DM+ yeast-BR; 2) the largest volume of drinking water and urine was in the DM + yeast-BR group; 3) absorbed diet in the DM + yeast-BR group was lower than the non-DM or DM + glibenclamide, but higher than the DM group; 4) The largest percentage of chromium absorbed by the small intestine was in the DM + yeast-BR group; 5) There was a correlation between reduction in blood glucose levels and the percentage of absorbed chromium in the DM + yeast-BR feed, but no correlation between reduction in blood glucose levels and the percentage of chromium absorbed in the Non-DM.