Effectivity of Curcumin and Thyroxine Supplementations for Improving Liver Functions to Support Reproduction of African Catfish (Clarias gariepinus)

Abstract

This experiment was designed to study the effect of curcumin and thyroxine supplementations on liver functions during the reproductive period of catfish. One hundred and twenty-eight African catfish (Clarias gariepinus) were assigned into a completely randomized design with a 2x2 factorial arrangement with four replications and each replication consisted of eight fish. The first factor was dose of curcumin supplementation which consisted of 2 levels i.e., 0 and 5 g kg-1feed. The second factor was dose of thyroxine supplementation consisting of 2 levels i.e., 0 and 0.1 mg.kg-1feed. The supplementation of curcumin and thyroxine hormone in catfish was given for 12 weeks. Results showed that the levels of serum vitellogenin concentrations, serum glutamic oxaloacetic transaminase (SGOT), and deoxyribonucleic acid (DNA from liver tissue in all groups did not show a significant difference (p>0.05). However, the concentration of malondialdehyde (MDA) in the liver tissue, the serum glutamic pyruvic transaminase (SGPT), and the ribonucleic acid (RNA) concentration in the liver tissue showed a significant difference (p<0.05). The supplementation of curcumin and thyroxine protect the liver, and increase the productivity of catfish liver function during the reproductive period.