Genetic polymorphism of drug metabolizing enzymes and their role in individual drug therapy

Abstract

Genetic polymorphism of drug metabolizing enzymes such as cytochrome P450 influences individual drug efficacy and safy through the alteration of pharmacokinetics and disposition of drugs. Considerable amounts of data are now accumulated for allelic differences of various enzymes. Here, current understanding of genotype information is summarized for their use on individual optimization of drug therapy. © 2002, THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM. All rights reserved.