Anti-cholinergic, cytotoxic and anti-HIV-1 activities of sesquiterpenes and a flavonoid glycoside from the aerial parts of Polygonum viscosum

Abstract

The anti-cholinergic, cytotoxic and anti-HIV-1 activities of four sesquiterpenes, viscosumic acid, viscozulenic acid, viscoazucine and viscoazulone, and a flavonoid glycoside, quercetin 3-O-9-(6″-feruloyl)- β-D-galactopyranoside, isolated from the aerial parts of Polygonum viscosum have been assessed. Among these compounds, quercetin 3-O-(6″-feruloyl)- β-D-galactopyranoside exhibited significant cytotoxic activity (IC 50 = 13.33 μg/mL) against the ovarian cancer cell line (OVCAR-3), anti-HIV-1 activity (IC50 = 25.61 μg/mL) and mild anti-cholinergic activity. Only one sesquiterpene, viscoazulone, showed anti-HIV-1 activity (IC50 = 33.13 μg/mL).