Exploring the landscape of stem cell research for Alzheimer’s disease: A bibliometric analysis spanning 2002–2021

Abstract

An increasing number of research on stem cells and Alzheimer's disease (AD) has been accomplished, making stem cells the research hotspot in the field. This study was conducted to identify the hotspots and trends of research related to stem cells and AD through a bibliometric analysis. A systematic search was performed in the Web of Science Core Collection database for relevant articles published from 2002 to 2021. Data were analyzed through Cite Space and VOS viewer. Stem cell research into AD covered 94 countries/regions, with a total of 3629 institutions participating, and showed an increasing trend every year, with the United States and China being the major countries studied. Takahashi’s team cultured the induced pluripotent stem cells for the first time, which became the source of many researchers’ theories. The University of California System is the organization with the most impact on research results. Plos One is the most popular journal. Maiese found that SIRT1 is the treatment target of AD, and his research results are the most. Research interests include brain, dentate gyrus, amyloid-beta, oxidative stress, neurodegeneration, inflammation, pluripotent stem cells, neutralistic stem cells, and microglia. Our study revealed the global research trend of stem cells in AD. At present, the research hotspot is the research of induced pluripotent stem cell models in AD. It provides important information and reference for researchers in this field.