Protective role of nrf2 in renal disease

74Citations
Citations of this article
68Readers
Mendeley users who have this article in their library.

Abstract

Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted to become by 2040 the fifth global cause of death. CKD is characterized by increased oxidative stress and chronic inflammation. However, therapies to slow or prevent CKD progression remain an unmet need. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that plays a key role in protection against oxidative stress and regulation of the inflammatory response. Consequently, the use of compounds targeting Nrf2 has generated growing interest for nephrologists. Pre-clinical and clinical studies have demonstrated that Nrf2-inducing strategies prevent CKD progression and protect from acute kidney injury (AKI). In this article, we review current knowledge on the protective mechanisms mediated by Nrf2 against kidney injury, novel therapeutic strategies to induce Nrf2 activation, and the status of ongoing clinical trials targeting Nrf2 in renal diseases.

Cite

CITATION STYLE

APA

Guerrero-Hue, M., Rayego-Mateos, S., Vázquez-Carballo, C., Palomino-Antolín, A., García-Caballero, C., Opazo-Rios, L., … Moreno, J. A. (2021, January 1). Protective role of nrf2 in renal disease. Antioxidants. MDPI. https://doi.org/10.3390/antiox10010039

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free