Influência da ciprofloxacina na consolidação óssea de fraturas de fêmur em ratos

Abstract

Objective: To present an experimental study about the effects of ciprofloxacin on the bone callus strength on femoral fractures in rats. Methods: The animals were divided in two groups of 8 rats each: the group study (cipro) and the control group. The animals were fixed with an intramedullary nail and submitted to a standardized femoral fracture. The group study was treated with ciprofloxacin and the control group with saline solution for six weeks. After that period, the femurs were analyzed using X-ray images and biomechanical three-point test, which measured the flexion strength in Newtons. Results: The X-ray images and the macroscopic analysis showed that all fractures healed. The results found in the biomechanical study between the two groups were compared, and the cipro group presented a mean resistance to flexion force of 71.11 and the contol group, mean flexion force of 74,78. There was no statistically significant difference (p = 0.601, t-test).Conclusion: The results from the biomechanical tests performed on femoral fractures in rats receiving ciprofloxacin revealed no statistical significance from measures of callus flexion strength when compared to the control group.