Expression and significance of miR-126 and miR-145 in infertility due to endometriosis

Abstract

The aim of this study was to determine the expression and significance of miR-126 and miR-145 in endometrial tissues in the mid-luteal phase of patients with infertility due to endometriosis. It was an experimental study carried out from January 2016 to July 2017. A total of 47 infertile patients with endometriosis were selected as an endometriosis group, and classified as 22 cases (46.81%) in stage I-II and 25 cases (53.19%) in stage III-IV; while 47 women who were infertile due to male factors were selected as a control group. The research showed that the expression levels of miR-126 and miR-145 in endometriosis group were higher than those of the control group (both p<0.001). There was no significant difference in the expression levels of miR-126 and miR-145 between the I-II and III-IV patients (p=0.535 and 0.809, respectively). The expression levels of miR-126 and miR-145 in endometrial tissues of non-pregnant patients were significantly higher than those of pregnant patients (both p<0.001). In conclusion, the up-regulated expression of miR-126 and miR-145 in the endometrial tissues in the mid-luteal phase of patients may play a role in infertility due to endometriosis.