Relationship between Fever Level and Leukocyte Levels in Children with Typhoid Fever

Abstract

Salmonella typhi spreads typhoid fever, a multisystem illness. The bacteria that cause typhoid fever may promote the generation of endotoxins that alter haematological assays, particularly those involving leukocytes. Exogenous pyrogens, such as bacteria or an immune reaction, produce fever. Pyogen may be an interleukin-1-like protein. This chemical may stimulate the hypothalamus to create more prostaglandin E2, causing fever. We also found lymphocytosis, monocytosis, eosinophilia, and thrombocytopenia. Endotoxin and endogenous mediators may reduce bone marrow, causing leucopenia. Recent research shows that the average leukocyte count is normal or slightly elevated, despite the idea that 25% of the population has leucopenia. This research examines whether fever and leukocyte counts are linked in hospitalized typhoid patients. This cross-sectional study was undertaken in the hospital's pediatrics and medical records departments. The sample included typhoid-hospitalized children. Forty persons were randomly recruited for this study. Chi-Square was used for univariate and multivariate analysis. (p = 0.816; OR = 1.181; 95% CI = 0.292-4.778). In typhoid-hospitalized youngsters, fever and leukocyte counts are unrelated.