Soluble Molecularly Imprinted Polymer-Based Potentiometric Sensor for Determination of Bisphenol AF

Abstract

Molecularly imprinted polymer (MIP)-based polymeric membrane potentiometric sensors have been successfully developed for determination of organic compounds in their ionic and neutral forms. However, most of the MIP receptors in potentiometric sensors developed so far are insoluble and cannot be well dissolved in the polymeric membranes. The heterogeneous molecular recognitions between the analytes and MIPs in the membranes are inefficient due to the less available binding sites of the MIPs. Herein we describe a novel polymeric membrane potentiometric sensor using a soluble MIP (s-MIP) as a receptor. The s-MIP is synthesized by the swelling of the traditional MIP at a high temperature. The obtained MIP can be dissolved in the plasticized polymeric membrane for homogeneous binding of the imprinted polymer to the target molecules. By using neutral bisphenol AF as a model, the proposed method exhibits an improved sensitivity compared to the conventional MIP-based sensor with a lower detection limit of 60 nM. Moreover, the present sensor exhibits an excellent selectivity over other phenols. We believe that s-MIPs can provide an appealing substitute for the traditional insoluble MIP receptors in the development of polymeric membrane-based electrochemical and optical sensors.