Dapsone syndrome with acute renal failure during leprosy treatment: Case report

Abstract

Dapsone syndrome is a rare hypersensitivity reaction to dapsone and is characterized by high fever, papular or exfoliative dermatitis, progressing to liver toxicity and generalized lymphadenopathy, resembling a mononucleosis infection. We report a patient who developed acute renal failure, as well as other complications characteristic of dapsone syndrome, during leprosy treatment. Renal involvement had not been previously described as a dapsone syndrome feature. © 2005 by The Brazilian Journal of Infectious Diseases and Contexto Publishing. All rights reserved.