Body composition changes in adult females after lifestyle intervention are influenced by the NYD-SP18 variant

Abstract

A) gene polymorphism and weight loss after lifestyle intervention (combined dietary intake and physical activity) in overweight/obese females. Methods: We genotyped 139 unrelated non-diabetic Czech females (49.5 ± 13.3 years, average BMI at baseline 32.2 ± 4.6 kg/m2). Biochemical and anthropometrical measurements were performed before and after ten weeks of lifestyle intervention. Results: The mean weight loss achieved was 4.7 ± 3.1 kg (p < 0.01). Carriers of the NYD-SP18 GG (N = 75) genotype lost significantly more body fat mass (p = 0.04) and gained more active muscle mass (p = 0.037) than the carriers of the A allele (N = 64). After adjustment of baseline values, both differences remained significant (p = 0.03 and p = 0.016). Conclusion: Overweight/obese female carriers of the NYD-SP18 rs6971091 GG genotype exhibited a more beneficial response to the intensive lifestyle intervention than others.