Z-band alternatively spliced PDZ motif protein (ZASP) is the major o-linked β-N-acetylglucosamine-substituted protein in human heart myofibrils

Abstract

Background: We studied O-GlcNAc-modified protein in sarcomeric proteins of human heart. Results: ZASP (Z-band alternatively spliced PDZ motif protein) accounts for 50-80% of O-GlcNAcylated protein. Conclusion: ZASP is the major O-GlcNAc-substituted protein in human heart muscle, and its levels increase in pathological muscle. Significance: Modulation of O-GlcNAcylation in ZASP may have a role in mechanotransduction in the heart.© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.