The relation between the RANKL and resistin in menopausal women with osteoporosis

Abstract

Osteoporosis (OP) is osteometabolic disease characterized by a decrease in bone mineral density(BMD) and due to the deterioration of bone architecture leading to spontaneous fractures. The aim of the current study is to evaluate the biomarkers include the; receptor activator of nuclear factor NF-κB ligand and Resistin . also measuring the biochemical include: estrogen, calcium, phosphorus, bone mineral density, t-scores in menopausal women with osteoporosis, and further more study the correlation between these biomarkers and biochemical. Method: This study was conducted at DEXA (dual-energy x-ray absorptiometry) Unit in Radiology Department in Al-Sader teaching hospital in AL-Najaf province /Iraq from January2018 to July 2018 to know the prevalence of osteoporosis in Iraqi menopausal women. A total of the (88) women involved in this study, blood samples had been taken from the (68) osteoporosis menopausal women, and from (20) women who were apparently healthy as a control group. Assays of study estimation of the parameters levels that include: Calcium, phosphorous were done by using auto biochemistry analyzer; Receptor activator of nuclear factor NF-κB ligand bone alkaline phosphatase, Resistin and estrogen, were measurement by using a solid phase enzyme-linked immunosorbent assay (ELISA).Result: The result of study showed a significant decrease (p< 0.05) in concentration of serum estrogen, calcium and phosphorus in menopausal women with osteoporosis compared with healthy group. The biomarker revealed a significant increase (p< 0.05) in the concentration of receptor activator of nuclear factor NF-κB ligand and Resistin in menopausal women with osteoporosis compared with healthy group. The study exhibited correlation coefficient and showed a significant (p< 0.05) negative correlation between BMD and receptor activator of nuclear factor NF-κB ligand. The study showed a significant negative (p< 0.05) correlation between estrogen and of nuclear factor NF-κB ligand. This study show significant (p< 0.05) positive correlation of receptor activator of nuclear factor NF-κB ligand with resistin.