Manipulating the epigenome in germinal center lymphomas: Is it getting easier and EZier?

Abstract

Mutations affecting key epigenetic modifiers tend to cluster in malignancies in which cells of origin lie in the germinal center (GC). EZH2, as transcriptional repressor, is mutated in high frequency in Chinese and Western patients with follicular lymphoma and may represent a rational target for GC-derived lymphomas. ©2014 AACR.