Spontaneous deposition of water-soluble substances into microcapsules: Phenomenon, mechanism, and application

Abstract

Water-soluble species can be deposited into preformed, multilayered polyelectrolyte capsules, templated onto melamine formaldehyde particles, with high integrity. Efficient encapsulation of albumin within capsules formed from a poly(styrene sulfonate)/poly(allylamine hydrochloride) composite was achieved at pH values below the isoelctric point of the protein through spontaneous deposition (see picture).