Gestational diabetes and risk assessment of adverse perinatal outcomes and newborns early motoric development

Abstract

Background and Objectives: The aim of this study was to analyze the presencf gestational diabetes mellitus (GDM) on maternal and fetal perinatal parameters, as well tvaluate the influencf GDM on neonataarly motoric development. Materials and Methods: In this prospectivtudy, wvaluated 203 eligible participants that were admitted tbstetrics department for a labor. GDM was assessed by evaluation of maternal parameters, fetal parameters, as well its impact on infants early motoric development (Alberta Infant Motor Scale—AIMS). Results: Presencf GDM was significantly positively associated with: Pre-pregnancy weight, obesity degree, weight at delivery, gestational weight gain (GWG), body mass index (BMI) at delivery, GWG and increased pre-pregnancy BMI, glucose levels in mother’s venous blood after the delivery, positivamily history for cardiovascular disease, pregnancy-related hypertension, congenital thrombophilia, drug use in pregnancy, largor gestational age (LGA), modf delivery (Cesarean section and instrumental delivery). Likewise, GDM association was detected for tested ultrasound parameters (biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), femoral length (FL)), length at birth, birth weight, newborn’s head circumference, newborn’s chest circumference, AIMupination and pronation at three months, AIMupination, pronation, sitting and standing at six months. Only Amniotic Fluid Index and AIMupination at three months of infant’s agemained significantly associated in multivariategression model. Conclusion: The presencf significant positive association of numerous tested parameters in outudy on perinatautcomes and early motoric development, points to the necessity of establishing appropriate clinical decision-makintrategies for all pregnant woman at risk and emphasize the importancf providing adequate glycaemia controptions and furtheegulaollow ups during the pregnancy.