Differential Effects of Cyclophosphamide on the B and T Cell Compartments of Adult Mice

Abstract

Adult mice were given a single sublethal dose of cyclophosphamide. Effects of the drug on the bone marrow-derived (B) and thymus-derived (T) cell compartments were measured by studies on lymphocyte transformation, lymphoid tissue morphology and responsiveness to a primary injection of keyhole limpet hemocyanin. These studies indicated that the effect of cyclophosphamide on the B cell compartment was more severe and longer-lasting than the effect on the T cell compartment.