Design, characterization and evaluation of curcumin-loaded mesoporous silica nanoparticles based topical drug delivery system for treatment of wrinkles

Abstract

Objective: The objective of research work was to development and evaluation of curcumin-loaded mesoporous silica nanoparticles (MSN), based topical dosage form for the treatment of facial wrinkles. Curcumin was selected as a hydrophobic model drug since it has been reported as potent anti-oxidizing and as an anti-wrinkle agent. Hence curcumin drug was selected as anti-wrinkle agent for the treatment of wrinkles. The MSN were prepared with tetraethyl ortho silicate and cetyltrimethyl ammonium bromide (as surfactant). The prepared MSN were characterized by using particle size analysis, scanning electron microscope, Xrd, FTIR and porosimetry. The MSN was found to be biocompatible chemically & thermally stable nanoparticles. The curcumin extract was loaded into MSN and incorporated into cream. In-vitro release study of curcumin-loaded MSN system was compared with marketed formulation and was found the curcumin-loaded mesoporous silica nanoparticles (MSN) showed good antioxidant activity and batter % cumulative drug release. The % cumulative drug release of curcumin-loaded MSN was found to be 88% at pH 5.5 and 85% at pH 7.4 respectively. Revealed that after incorporation of curcumin into MSN, the drug release rate was found increased. The properties of curcumin-loaded MSN strongly advocate its good feature for delivery of anti-wrinkles drug. The prepared curcumin-loaded MSN seem to have potential carrier for use as a topical drug delivery.