Antibacterial therapy of community-acquired pneumonia

Abstract

Cephalosporins, and primarily ceftriaxone, were the main group of antibiotics used as monotherapy in case of community-acquired pneumonia of inpatient treatment. Macrolides and fluoroquinolones have been used predominantly in combination with cephalosporins (ceftriaxone, ceftazidime, cefuroxime, cefazolin) in patients with comorbidities. The selection of empirical antibacterial preparations was based on subjective, objective, laboratory and radiological data, as well as by analyzing epidemiological data and antibacterial resistance in hospital. The optimal strategy in the selection of antibiotics or their combinations is determined by covering spectrum of possible microbial agents, obtaining a synergistic antimicrobial effect and avoiding potential adverse reactions.