Abstract
In this observational study, 13 patients with severe COVID-19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID-19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible new form of biological target therapy.
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Fenoglio, D., Dentone, C., Parodi, A., Di Biagio, A., Bozzano, F., Vena, A., … Filaci, G. (2021). Characterization of T lymphocytes in severe COVID-19 patients. Journal of Medical Virology, 93(9), 5608–5613. https://doi.org/10.1002/jmv.27037
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