Attractor dynamics with activity-dependent plasticity capture human working memory across time scales

Abstract

Most cognitive functions require the brain to maintain immediately preceding stimuli in working memory. Here, using a human working memory task with multiple delays, we test the hypothesis that working memories are stored in a discrete set of stable neuronal activity configurations called attractors. We show that while discrete attractor dynamics can approximate working memory on a single time scale, they fail to generalize across multiple timescales. This failure occurs because at longer delay intervals the responses contain more information about the stimuli than can be stored in a discrete attractor model. We present a modeling approach that combines discrete attractor dynamics with activity-dependent plasticity. This model successfully generalizes across all timescales and correctly predicts intertrial interactions. Thus, our findings suggest that discrete attractor dynamics are insufficient to model working memory and that activity-dependent plasticity improves durability of information storage in attractor systems.