The Effect of Several Commonly Used Antipsychotic Drugs on the Renal Function of Patients with Mental Illness

Abstract

Objective: To understand the effects of several commonly used antipsychotics on the renal function of patients with mental illness. Method: Collected patients with mental illness who were hospitalized in our hospital from January 2020 to June 2021, and selected as the research subjects patients with psychiatric disorders who were treated with 2 kinds of commonly used antipsychotic drugs; and collected 3 ml of venous blood before treatment and one month after treatment for renal function tests; observed the changes of renal function indexes before and after treatment. Results: In the collected 694 patients with mental illness, before using antipsychotic drugs, the renal function indexes were BUN: 4.42 ± 1.92 mmol/l; Cr: 70.97 ± 16.92 μmol/l; CCr: 88.37 ± 21.07 ml/min; β2-MG: 1.67 ± 0.61 mg/L; UA: 359.90 ± 112.82 μmol/l; CYS-C: 0.92 ± 0.24 mg/L. One month after using antipsychotics, BUN: 3.77 ± 1.37 mmol/l; Cr: 70.46 ± 16.71 μmol/l; CCr: 87.78 ± 20.63 ml/min; β2-MG: 1.75 ± 0.64 mg/L; UA: 332.53 ± 91.48 umol/l; CYS-C: 0.92 ± 0.24 mg/L; the renal function indexes of urea nitrogen, β2 microglobulin, uric acid and other items all changed significantly. The differences before and after treatment were statistically significant, P < 0.01. Conclusion: Several commonly used antipsychotic drugs have a greater impact on the renal function of patients with mental illness. During the treatment, the changes in renal function should be monitored regularly, if severe renal damage is found, the treatment plan or dosage should be adjusted in time to avoid endangering life.