Advancements in capillary-assembled microchip (CAs-CHIP) development for multiple analyte sensing and microchip electrophoresis

Abstract

This review describes advancements toward the development of a capillary-assembled microchip (CAs-CHIP) for simultaneous multiple analyte sensing and microchip capillary electrophoresis. Development of such an advanced system relies on several factors such as improving the fluid handling technique, creating new biosensing mechanisms, and integrating different functional capillaries into a single CAs-CHIP system. Furthermore, we provide an overview of various functional capillaries that have been established for valving and biosensing applications such as ions, metabolites,proteins, and enzyme activities. We also highlight future prospects for CAs-CHIP development as related to highthroughput systems, facile fluid handling, and mass production. © 2014 The Japan Society for Analytical Chemistry.