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Hepatic Ischemia/Reperfusion Injury Is Diminished by Atorvastatin in Wistar Rats

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Abstract

Background and Aims: Temporal occlusion of the hepatoduodenal ligament (HDL) is often used during liver surgeries in order to reduce blood loss, resulting in ischemia/reperfusion injury (I/R). The aim of the study was to investigate the effects of atorvastatin (ATOR) on hepatic I/R injury and on serum levels of tumor necrosis factor-alpha (TNF-α), endothelin-1 (ET-1), antithrombin III (ATIII) and intracellular adhesion molecule-1 (ICAM-1). Methods: Liver ischemia was induced in Wistar rats by clamping the HDL for 60 min, followed by either 60 or 180 min reperfusion. Rats received either vehicle or 10 mg/kg ATOR before hepatic I/R. Control group received sham surgery. Livers were examined for histological damage and serum AST, ALT, TNF-α, ET-1, ATIII and ICAM-1 concentrations were measured. Results: After I/R, AST and ALT were significantly elevated, ATIII levels were significantly depleted, both TNF-α and ICAM-1 levels increased and ET-1 was significantly elevated (at 180 min). ATOR pretreatment attenuated these alterations and diminished histological injury scores. Conclusions: Our results show that ATOR protects the liver from I/R injury. © 2014 IMSS.

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Cámara-Lemarroy, C. R., Guzmán-de la Garza, F. J., Alarcón-Galván, G., Cordero-Pérez, P., Muñoz-Espinosa, L., Torres-González, L., & Fernández-Garza, N. E. (2014). Hepatic Ischemia/Reperfusion Injury Is Diminished by Atorvastatin in Wistar Rats. Archives of Medical Research, 45(3), 210–216. https://doi.org/10.1016/j.arcmed.2014.02.001

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