In situ generation and diels-alder reaction of benzynes derivatives with 5-membered ring heterocycles using a microcapillary flow reactor

Abstract

The formation of benzynes derivatives from ortho-trimethylsilyl triflates using tetra-n-butylammonium fluoride (TBAF) as the benzyne-forming trigger was achieved in a straightforward flow reactor at room temperature. These benzynes were immediately trapped in Diels-Alder reactions to deliver the desired cycloadducts.