Synthesis, characterization and superoxide dismutase Actwity of the Manganese(II) mixed ligand complexes containing sulfathiazole

Abstract

Manganese(II) metal ion and sulfathiazole (Hstz) react with pyrrolidine (pyrro), piperidine (pipe) and ethylenediamine (en) to form the following mixed ligand complexes : [Mn(stz)2(pyrro)2], [Mn(stz)2(pipe)J and [Mn(stz)2(en)2] which were characterized by physicochemical and spectroscopic methods. Their spectra indicated that the sulfathiazole is probably acting as amonoanionic unidentate chelating agent. The superoxide dismutase mimetic activity of the complexes was investigated using the indirect xanthine-xanthine oxidase-nitroblue tetrazolium method and compared to that of the native enzyme. © 2009 Sociedad Chilena de Química.