Surgical treatment for pulmonary pleomorphic carcinoma: A retrospective study of 60 patients

Abstract

Background: Pleomorphic carcinoma is a rare epithelial malignant tumor. Because the clinical characteristics and behavior of the disease remain unclear, we investigated the clinicopathological findings and prognosis of 60 patients with pleomorphic carcinoma. Methods: The clinicopathological characteristics of 60 cases of pulmonary pleomorphic carcinoma identified between 1999 and 2011 were studied. Of these, 55 patients had peripheral disease and five had central disease. The tumor size in all patients was 1-9.5cm (mean, 5.8 ± 4.5cm), while 30 had lesions with a diameter larger than 5cm. All patients underwent pulmonary resection. Results: There were no in-hospital deaths. The three and five year survival rates of all patients were 47.2% and 25.6%, respectively. The three and five year survival rates were 57.3% and 32.5% for N0 patients, and 25.4% and 17.1% for N1-2 patients, respectively. Overall survival was significantly different between the radical resection and incomplete resection groups. Multivariate Cox regression analyses of overall survival for all 60 patients indicated that radical resection (P = 0.041), tumor node metastasis (TNM) stage (P = 0.044), and nodal status (P = 0.029) were significant independent prognostic factors. Conclusion: Pleomorphic carcinoma is a rare type of lung cancer. In our study, pleomorphic carcinoma of the lung was often found as a peripherally located large mass and was associated with a poor prognosis. Radical resection, TNM stage and nodal status were significant independent prognostic factors. © 2013 Tianjin Lung Cancer Institute and Wiley Publishing Asia Pty Ltd.