Normal pregnancy in multiple myeloma treated with cyclophosphamide

Abstract

We have studied a young woman with multiple myeloma who became pregnant while on oral cyclophosphamide. She had a normal pregnancy and was delivered by cesarean section because of fetal distress. The infant was healthy at birth and had an “M” component in serum of cord blood similar to his mother's. This abnormal protein disappeared when the infant was evaluated at 2 years of age. We conclude that the abnormal IgG in multiple myeloma can cross the placental barrier, but the newborn did not have any detectable disease. Chromosomal studies on the newborn were normal. Cyclophosphamide therapy produced no evident congenital abnormalities. A review of three additional instances of pregnancy and multiple myeloma is made, with a reveiw of the pertinent literature concerning pregnancy and cyclophosphamide therapy. Copyright © 1974 American Cancer Society