Transplantation for chemotherapy-induced cardiomyopathy—case series and review of current practice

Abstract

Multimodality therapies have improved the survival after tumors like Ewing’s sarcoma and breast cancer. However, cardiotoxicity following chemotherapy remains an important concern. We report a case series of four patients who presented to our heart team with severe dilated cardiomyopathy along with biventricular involvement. Two of the patients were females and had breast cancer for which they were treated with trastuzumab and had developed chemotherapy induced cardiomyopathy (CCMP). The other two patients were males who had Ewing’s sarcoma who developed CCMP following treatment with doxorubicin.