PTU-165 The Better Definition of Nodal Staging in the 7Th Edition of TNM Manual does not Predict Survival or Translates into better Prognosticating Ability in Oesophago-Gastric Junctional Adenocarcinoma

Abstract

Aims: To study the impact of the 7th TNM staging on nodal neo-staging (N) of resected and pathologically reported oesophago-gastric junctional adenocarcinomas (OGJA), compare the original staging and assess possible impact of N on overall survival (OS). Methods: A retrospective database containing data of all consecutive curative resections of OGJA over 10 years was obtained. Any report with less than 12 lymph nodes was considered inadequate. All N and OS was analysed. OS was sub-stratified into 2, 5 and 10 years post curative resection. Results: 57 pathology reports confirming OGJA were reviewed. Adequate lymphadenectomy (ALN) was noted in 33 patients. N was noted in 36. Of those who had ALN (33), 20 had stage migration. Two year survival (n=57), 5 year survival for patients operated between 2000 to 2007 (n=34) and 10 year survival for patients treated between 2000 to 2002 (n=10) was analysed. For stage 3b and stage 3c, therewas a 12.5%, 8.9% and 8.9% higher survival rate respectively. Correspondingly for stage 1b, the survival rate was 5.3%, 3.6% and 3.6% respectively. Conclusion: The 7thTNMstaging better defines lymphatic staging, but does not seem to predict survival or have a superior prognosticating ability.