Anticonvulsant activity of Shankhapuspi (Convolvulus pluricaulis Chois) on Strychnine induced seizure in experimental animals

Abstract

The anticonvulsant activity of the aqueous extract of Convolvulus pluricaulis Chois (Shankhapuspi) was studied against Strychnine induced convulsions. Seizure was induced by Strychnine in Shankhapuspi used animal model. The co-administration of the standard anticonvulsant drug Phenytoin sodium and aqueous extract of Shankhapuspi resulted in significant anticonvulsant activity when compared to the anticonvulsive activity of Phenytoin sodium. The results of the study clearly suggested that Shankhapuspi can be prescribed as a co-therapeutic agent of Phenytoin for arresting seizures induced by Strychnine.