Investigation of the DAOA/G30 locus in panic disorder

Abstract

The authors assessed whether genetic variation at the DAOA/G30 locus contributes to panic disorder (PD) and analyzed five SNPs at this locus in 152 patients and 208 controls. In the single-locus analyses, three SNPs were significantly associated with PD. Further support was obtained at the haplotypic level. Given that the authors have previously observed the same alleles and haplotypes to be associated with bipolar affective disorder and schizophrenia, the results suggest that DAOA/G30 contributes to psychiatric disease beyond diagnostic boundaries. © 2005 Nature Publishing Group. All rights reserved.