Biginelli condensation of aliphatic aldehydes catalysed by zinc methanesulfonate

Abstract

Three-component condensation of an aliphatic aldehyde, 1,3-dicarbonyl compound and urea proceeds efficiently in absolute ethanol under refluxing temperature using zinc methanesulfonate as a catalyst to afford corresponding 3,4-dihydropyrimidinone. The catalyst can be reused for several times without distinct decrease in reaction yields. The procedure is very useful for the synthesis of dihydropyrimidinones with a wide range of aliphatic aldehydes.