Sequence of the full length immunoglobulin κ chain of mouse myeloma MPC 11

Abstract

MPC 11 mouse myeloma cells synthesize two immunoglobulin κ light chains, coded by two separate genes. One of these κ-chains has no variable region and is degraded intracellularly. The other is a full-length κ-chain containing both variable and constant regions; this chain is secreted, both by itself and combined with heavy chains in molecules of full-length κ-chain. The chain is unusual in having 12 extra residues at its N-terminus when its sequence is aligned with those of other mouse κ-chains; no other anomalies were found in its sequence.