Blood-oxygenation-level-dependent-(BOLD-) based R2(′) MRI study in monkey model of reversible middle cerebral artery occlusion

Abstract

Objective. To investigate the value of BOLD-based reversible transverse relaxation rate (R2(′)) MRI in detecting ischemic penumbra (IP) in a monkey model of reversible middle cerebral artery occlusion (MCAO) and time evolution of relative R2(′) (rR2(′)) in infarcted core, IP, and oligemia. Materials and Methods. 6 monkeys were used to make MCAO by the microcatheter method. MR scans were performed at 0h (1h after MCAO), 1h, 3h, 6h, 12h, 24h, and 48h after reperfusion. R2(′) was calculated using quantitative T2 and T2() maps. Ischemic area was subdivided into infracted core, IP and oligemia. rR2(′) was calculated respectively. Results. Reversible MCAO model for 4/6 monkeys was made successfully. rR2(′) values were significantly different at each time point, being highest in oligemia followed by IP and infarcted core (P